KINDEW(Amisulpride) |
KINDEW (Amisulpride) is an antiemetic and antipsychotic cure utilized at lower
portions intravenously to obstruct and treat postoperative illness and
disgorging; and at higher pieces by mouth to treat schizophrenia and uncommon
contorted scenes.
Formula: C17H27N3O4S
Molar mass: 369.48 g/mol
Metabolism: Liver (minimal; most excreted unchanged)
Protein binding: 16%
Elimination half-life: 12 hours
A HEALTHY MIND IS THE GREATEST TREASURE TO FINE |
Mechanism of Action |
ü KINDEW (Amisulpride) blocked presynaptic dopamine D2 Receptors.
ü These presynaptic Receptors regulate the release of dopamine into the
synapse.
ü So blocking than KINDEW (Amisulpride) increase dopamine concentration in the synapse.
ü This increase dopamine concentration is theorized to act on dopamine D1
Receptors to relive depressive symptoms (dysthymia) and the negative symptoms
of schizophrenia.
Benefits of KINDNEW |
Ø KINDEW (Amisulpride) has
better responder v/s Risperidone & Olanzapine.
Ø KINDEW (Amisulpride) is
a typical antisychotic D2,.D3 antagonist.
Ø KINDEW (Amisulpride)
has no affinity for dopamine D1, D4, D5 Receptors subtype.
Ø KINDEW (Amisulpride)
has no effect on prolactin.
Daily Dosage: |
v KINDEW (Amisulpride) as
an antiemetic 50-100mg/day
v KINDEW (Amisulpride) as
an antipsychotic 200 – 400mg/day.
Indications: |
>
Dysthymia
Schizophrenia
Acute psychotic
Episodes.
Imbalance of
Chemical Substances Acting on Nvs
Nausea &
Vomiting
Drug included
Nausea, Vomiting
Postoperative Nausea,
Vomiting
Nausea, Vomiting
Associated with Chemical Therapy.
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A
HEALTHY MIND IS THE GREATEST TREASURE TO FINE |
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| Rmskameer KINDEW tablet (Amisulpride)-Review-Uses-Side-Effects-and-More |
-Review-Uses-Side-Effects-and-More){kind=link}